Top Hotels in Cape Girardeau for Memorable Stays

We checked thousands of reviews on and to find the best hotels for your stay
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Quinnton Powell

Updated: 29 February 2024 · 5 min

Nestled along the mighty Mississippi River, Cape Girardeau is a hidden gem waiting to be discovered. This charming city, with its rich history and vibrant cultural tapestry, offers a unique blend of Southern hospitality and Midwestern charm. For travelers looking to explore this enchanting locale, finding the perfect hotel in Cape Girardeau is the first step to an unforgettable journey.

Cape Girardeau's accommodations range from luxurious, full-service hotels to cozy, boutique inns, ensuring that every traveler finds their ideal stay. Whether you're in town for business, a romantic getaway, or a family vacation, the city's hotels are designed to provide comfort, convenience, and access to the area's top attractions. Recommendations from seasoned travelers often highlight the riverside views and proximity to historic downtown as must-haves for any hotel stay in Cape Girardeau.

Moreover, choosing the right hotel in Cape Girardeau can enhance your experience of the city. Many hotels offer guests exclusive insights into the local culture, with amenities such as guided tours, themed decor, and dining options featuring locally sourced ingredients. With a carefully selected hotel, your stay in Cape Girardeau becomes more than just a trip—it transforms into a deep dive into the heart and soul of this captivating corner of the United States.
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Our Top 9

(Sorted by rating & number of reviews)

1. Town House Inn Cape Girardeau
2. Candlewood Suites Cape Girardeau, An Ihg Hotel
3. Drury Inn & Suites Cape Girardeau
4. Drury Plaza Hotel Cape Girardeau Conference Center
5. Auburn Place Hotel & Suites Cape Girardeau
6. Quality Inn
7. Courtyard By Marriott Cape Girardeau Downtown Hotel
8. Pear Tree Inn Cape Girardeau Medical Center
9. Holiday Inn Express Hotel & Suites Cape Girardeau I-55, An Ihg Hotel

Budget-Friendly Hotels in Cape Girardeau MO

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Cape Girardeau
Feb 23, 2026 - Feb 24, 2026

Town House Inn Cape Girardeau

5.3

Good

(93 Reviews)

+ -1 photos
For those who appreciate the balance between cost and convenience, the Town House Inn Cape Girardeau is a standout option. This establishment prides itself on its friendly service, clean rooms, and a location that’s just minutes away from the heart of the city. Guests can enjoy free internet access and on-site parking, making it an ideal choice for both business travelers and tourists. The hotel's commitment to providing a comfortable stay at an affordable price is evident in every aspect of its operation.
Address: 505 North Kingshighway Street
Rating: Good 5.3 (93 Reviews)
Rooms: 38
Price: From 70$

Candlewood Suites Cape Girardeau, An Ihg Hotel

8.5

Good

(78 Reviews)

+ 57 photos
Candlewood Suites Cape Girardeau provides a luxurious home away from home. This all-suite hotel caters to both short-term and extended stays, offering spacious accommodations with fully equipped kitchens. Guests can take advantage of the on-site gym, free laundry facilities, and outdoor gazebo grill. Its location near major attractions and business hubs, along with thoughtful amenities like a lending locker for appliances, ensures both convenience and comfort for all guests.
Address: 485 South Mt. Auburn Road
Rating: Good 8.5 (78 Reviews)
Rooms: 85
Price: From 159$

Luxury and Full-Service Hotels in Cape Girardeau MO

For travelers looking to indulge in the finer things while visiting Cape Girardeau the city offers several luxurious and full-service hotels. These establishments are designed to provide an unparalleled hospitality experience, with premium amenities, exquisite dining options, and exceptional service. Whether it's for a special occasion or simply to enjoy a touch of luxury, these hotels promise to elevate your stay in Cape Girardeau to the next level.

Drury Inn & Suites Cape Girardeau

8.9

Good

(371 Reviews)

+ 77 photos
The Drury Inn & Suites Cape Girardeau is recognized for its commitment to making family stays as comfortable and enjoyable as possible. Families can benefit from the hotel's free hot breakfast, indoor pool, and pet-friendly policy. The hotel also offers complimentary evening snacks and drinks, adding an extra level of convenience for families. Its rooms are designed to accommodate groups of various sizes, ensuring a comfortable fit for everyone.
Address: 3303 Campster Drive
Rating: Good 8.9 (371 Reviews)
Rooms: 42
Price: From 73$

Drury Plaza Hotel Cape Girardeau Conference Center

9.3

Good

(421 Reviews)

+ 52 photos
At the Drury Plaza Hotel Cape Girardeau Conference Center, guests are treated to a lavish experience. This hotel boasts an indoor/outdoor pool, a 24-hour fitness center, and on-site dining options. Each room is elegantly furnished, offering a comfortable and stylish retreat. The hotel's location near the Mississippi River provides stunning views, making it a picturesque setting for both leisure and business stays. Complimentary perks such as free breakfast and evening drinks add to the luxurious experience.
Address: 3351 Percy Drive
Rating: Good 9.3 (421 Reviews)
Rooms: 238
Price: From 115$

Family-Friendly Hotels in Cape Girardeau MO

Traveling with family comes with its own set of expectations and requirements when it comes to accommodations. In Cape Girardeau several hotels stand out for their family-friendly amenities and services. From spacious rooms to engaging activities for young travelers, these hotels aim to make every family's stay enjoyable and stress-free.

Auburn Place Hotel & Suites Cape Girardeau

8.3

Good

(830 Reviews)

+ 45 photos
Auburn Place Hotel & Suites in Cape Girardeau is a haven for families. With an indoor pool, free breakfast, and a cozy outdoor patio, there’s something for every member of the family to enjoy. The rooms are spacious and well-equipped to accommodate families, offering both comfort and convenience. The hotel’s location near family-friendly attractions, coupled with its welcoming atmosphere, makes it an ideal choice for a memorable family stay.
Address: 3265 William Street
Rating: Good 8.3 (830 Reviews)
Rooms: 103
Price: From 69$

Quality Inn

7.4

Good

(192 Reviews)

+ 52 photos
Quality Inn stands out as a budget-conscious hotel offering more than just a place to rest your head. Here, guests can enjoy an outdoor pool, a complimentary hot breakfast, and a fitness center. Each room is equipped with a refrigerator and microwave, adding convenience for longer stays. The hotel's location allows easy access to both downtown Cape Girardeau and the surrounding natural beauty. It's an excellent choice for travelers seeking comfort and value.
Address: 2011 N. Kingshighway St.
Rating: Good 7.4 (192 Reviews)
Rooms: 49
Price: From 109$

Courtyard By Marriott Cape Girardeau Downtown Hotel

9.0

Good

(182 Reviews)

+ 20 photos
The Courtyard By Marriott Cape Girardeau Downtown seamlessly combines luxury with modern convenience. Located in the heart of the city, this hotel offers easy access to Cape Girardeau’s best dining, shopping, and entertainment options. Guests can enjoy the on-site restaurant, fitness center, and stylish rooms equipped with the latest technology. The hotel's dedication to guest satisfaction and its contemporary design make it a premier choice for those seeking a sophisticated stay.
Address: 400 Broadway Street
Rating: Good 9.0 (182 Reviews)
Rooms: 91
Price: From 124$

Pear Tree Inn Cape Girardeau Medical Center

8.4

Good

(845 Reviews)

+ 28 photos
The Pear Tree Inn Cape Girardeau Medical Center is the epitome of economical comfort. This hotel offers guests free Wi-Fi, a complimentary breakfast, and access to a fitness center, all without the hefty price tag. Its proximity to the medical center makes it ideal for those visiting for health-related reasons, but it's also just a short drive from the city's main attractions. The welcoming staff and clean, comfortable rooms ensure that all guests have a pleasant and hassle-free stay.
Address: 3248 William Street
Rating: Good 8.4 (845 Reviews)
Rooms: 78
Price: From 75$

Holiday Inn Express Hotel & Suites Cape Girardeau I-55, An Ihg Hotel

8.8

Good

(334 Reviews)

+ 60 photos
Holiday Inn Express Hotel & Suites in Cape Girardeau I-55 offers families a comfortable and convenient base for their adventures in the city. Guests can start their day with a complimentary breakfast and then explore nearby attractions. The hotel features an indoor pool and a fitness center, perfect for family fun and relaxation. Its spacious suites, equipped with microwaves and refrigerators, add an element of home-like comfort, making it an excellent option for families traveling to Cape Girardeau.
Address: 3253 William Street
Rating: Good 8.8 (334 Reviews)
Rooms: 102
Price: From 144$